The Numbler (Dana Gould) is rumored to have been driven mad trying to find the square root of pi. He injects his henchmen with the Pythagorean Serum to give them the proportional speed and strength of a right triangle. He's a really good boss, actually, althought he thinks Shape Ape is obtuse.
His deathtrap is the Subtraction Matrix, which makes one feel derivative and unable to function; ultimately, it tears you apart on a molecular level. His secret lair is the Googleplex.
In Three Sides to Every Story, Adventurekateer Omar says that the Numbler retired from crime and is now known as Cardinal Numbler, who has opened the Fifteen Chapel on the east side of Apex City. Soon, ground will be broken on the west side of Apex City for the Sixeteen Chapel.